Disease of high blood pressure became silent killer after causing
disturbance of heart function, kidney, cognitive, and stroke. Azizahwati, Lecturer
and also researcher from Department of Pharmacy Faculty of Mathematics and
Natural Sciences University of Indonesia, diversifying antihypertensive drug dosage form
of herbal capsules avocado leaves.
Azizahwati presented the Final Report of Research Grants, University of Indonesia (UI) in 2010. She researched encapsuled avocado leaf extract (Persea americana Mill) with a team from the Department of Pharmacology Faculty of Medicine, UI. They are H Purwaningsih Erni, Endang Hanani, and Sutriyo. They obtained the UI research grants in 2010 amounted to Rp 164.8 million.
According to the Head of Sub-Directorate of Research and Industry Incubator Yasman UI, The UI research grants came from the Community Fund Program which is taken from the operational cost of education (BOP) submitted by each student enrolled. The year 2010, The Community Fund Program provided grants for 199 research activities.
Categories of activities include initial research, graduate, seeded, and multidisciplinary. Large fund of Rp 40 million (preliminary research) to Rp 175 million (multidisciplinary research). "The principal investigator is required from the UI," said Yasman.Yasman added, Research is undertaken largely to satisfy the curiosity of the professors or raise the Community Fund Program archers, so the percentage of research results that can be applied to society and industry is still relatively small. However, the team Azizahwati prove sufficiently applied their research to provide an alternative packaging and herbal medicinal products.
Azizahwati say, Antihiperlipidemia as antihypertensives, Avocado leaf capsules has been demonstrated as antihiperlipidemia. Hyperlipidemia is a condition caused by the fat content or cholesterol is too high in the blood.
For patients with hypertension and obesity is a characteristic of them. Pump power of heart and circulatory blood volume in obese patients with hypertension will be higher compared with patients who have normal weight.
For those who have hyperlipidemia, fatty diet a major cause. This was coupled with a sedentary lifestyle that triggers hyperlipidemia.
Hyperlipidemia is one of the triggers of heart attacks, that is when cholesterol in the blood that settles as a plaque on blood vessel walls to collapse and clog blood vessels. Hypertension and hyperlipidemia become the highest cause of death today.
Azizahwati said, research encapsuled avocado leaves that will be used as herbal medicinal products commensurate phytopharmaca.
Phytopharmaca be prescribed like drugs made from synthetic chemicals. Process towards phytopharmaca must pass clinical trials in humans.
Azizahwati research is still at the level of preclinical testing, ie test in mice (mice). Research results showed that ethanol extract of avocado leaves have antihiperlipidemia effect.
Mice were divided into three groups and given the leaf extract of avocado with each dose of 10 milligrams per kilogram of body weight (mg / kg), 20 mg / kg, and 40 mg / kg. Groups of mice were tested with avocado leaf extract dose of 40 mg / kg gave the best results.
Ethanol extracts of avocado leaves are also known to function as an antihypertensive in the dose of 40 mg / kg. Ability to reduce arterial blood pressure an average of male and female mice at 58 mmHg and 54.5 mmHg.
To be suffering from hyperlipidemia, induced murine yolk or other animal fat into her body. The condition of hypertension induce mice obtained by salt.
Dryers are used for avocado leaves is Avicel PH 101 with a ratio of 1:0,75 and the addition of Aerosil 8.3 percent.
The use of Avicel PH 102 is mentioned as the best formula because it has a mass density (bulk density) and the greatest flow rate. The result contains a compressibility index, water content, and destroyed most small time.
Maceration
Preparation of avocado leaf extract made by maceration with 70 percent alcohol. Maceration is the soaking to remove the active compounds in powder avocado leaves. A total of 300 grams of powder avocado leaves macerated with alcohol 70 per cent, until it reaches a yield of 29 percent.
Capsules avocado leaves become standardized herbal medicine remains to be developed into phytopharmaca. Azizahwati still requires further research with clinical trials in humans.
For ordinary people, not pictured avocado leaves can provide the benefits of lowering blood pressure and high fat content. Hypertension and high cholesterol is a threat of disease that many people whack.
Research Azizahwati is managed to open the eyes of all levels of society. Natural resources around us is quite significant in providing health benefits.
Azizahwati presented the Final Report of Research Grants, University of Indonesia (UI) in 2010. She researched encapsuled avocado leaf extract (Persea americana Mill) with a team from the Department of Pharmacology Faculty of Medicine, UI. They are H Purwaningsih Erni, Endang Hanani, and Sutriyo. They obtained the UI research grants in 2010 amounted to Rp 164.8 million.
According to the Head of Sub-Directorate of Research and Industry Incubator Yasman UI, The UI research grants came from the Community Fund Program which is taken from the operational cost of education (BOP) submitted by each student enrolled. The year 2010, The Community Fund Program provided grants for 199 research activities.
Categories of activities include initial research, graduate, seeded, and multidisciplinary. Large fund of Rp 40 million (preliminary research) to Rp 175 million (multidisciplinary research). "The principal investigator is required from the UI," said Yasman.Yasman added, Research is undertaken largely to satisfy the curiosity of the professors or raise the Community Fund Program archers, so the percentage of research results that can be applied to society and industry is still relatively small. However, the team Azizahwati prove sufficiently applied their research to provide an alternative packaging and herbal medicinal products.
Azizahwati say, Antihiperlipidemia as antihypertensives, Avocado leaf capsules has been demonstrated as antihiperlipidemia. Hyperlipidemia is a condition caused by the fat content or cholesterol is too high in the blood.
For patients with hypertension and obesity is a characteristic of them. Pump power of heart and circulatory blood volume in obese patients with hypertension will be higher compared with patients who have normal weight.
For those who have hyperlipidemia, fatty diet a major cause. This was coupled with a sedentary lifestyle that triggers hyperlipidemia.
Hyperlipidemia is one of the triggers of heart attacks, that is when cholesterol in the blood that settles as a plaque on blood vessel walls to collapse and clog blood vessels. Hypertension and hyperlipidemia become the highest cause of death today.
Azizahwati said, research encapsuled avocado leaves that will be used as herbal medicinal products commensurate phytopharmaca.
Phytopharmaca be prescribed like drugs made from synthetic chemicals. Process towards phytopharmaca must pass clinical trials in humans.
Azizahwati research is still at the level of preclinical testing, ie test in mice (mice). Research results showed that ethanol extract of avocado leaves have antihiperlipidemia effect.
Mice were divided into three groups and given the leaf extract of avocado with each dose of 10 milligrams per kilogram of body weight (mg / kg), 20 mg / kg, and 40 mg / kg. Groups of mice were tested with avocado leaf extract dose of 40 mg / kg gave the best results.
Ethanol extracts of avocado leaves are also known to function as an antihypertensive in the dose of 40 mg / kg. Ability to reduce arterial blood pressure an average of male and female mice at 58 mmHg and 54.5 mmHg.
To be suffering from hyperlipidemia, induced murine yolk or other animal fat into her body. The condition of hypertension induce mice obtained by salt.
Dryers are used for avocado leaves is Avicel PH 101 with a ratio of 1:0,75 and the addition of Aerosil 8.3 percent.
The use of Avicel PH 102 is mentioned as the best formula because it has a mass density (bulk density) and the greatest flow rate. The result contains a compressibility index, water content, and destroyed most small time.
Maceration
Preparation of avocado leaf extract made by maceration with 70 percent alcohol. Maceration is the soaking to remove the active compounds in powder avocado leaves. A total of 300 grams of powder avocado leaves macerated with alcohol 70 per cent, until it reaches a yield of 29 percent.
Capsules avocado leaves become standardized herbal medicine remains to be developed into phytopharmaca. Azizahwati still requires further research with clinical trials in humans.
For ordinary people, not pictured avocado leaves can provide the benefits of lowering blood pressure and high fat content. Hypertension and high cholesterol is a threat of disease that many people whack.
Research Azizahwati is managed to open the eyes of all levels of society. Natural resources around us is quite significant in providing health benefits.
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